Ginger reduced colorectal cancer risk in human Phase II study

Health Science and Practical Remedies
科学诊断,有效疗法,中医精华,养生防病


Ginger (Rhizomes of Zingiber officinale) is one of the most widely used spice and condiment.
Ginger and its active compounds are stimulants, carminative, antioxidant, anti-inflammatory, antiemetic and gastroprotective.

Inflammatory mediator eicosanoids such as prostaglandin E(2) (PGE(2)), produced by cyclooxygenase (COX) are early events in the development of colorectal cancer. Ginger has shown down-regulation of COX and decreased incidence or multiplicity of adenomas in rats.

30 Human subjects were grouped to 2 grams of ginger extract per day or placebo for 28 days. A liquid chromatography mass spectrometry method was used to determine eicosanoid levels in the human biopsies. There was no difference between the groups in terms of total adverse events. Ginger has decreased inflammatory mediator eicosanoid levels by inhibiting their synthesis from arachidonic acid.

Ginger has been extensively used in Chinese, Ayurvedic, Tibb-Unani, Srilankan, Arabic, and African traditional medicines, since antiquity, for many unrelated human ailments including common colds, fever, sore throats, vomiting, motion sickness, dyspepsia, gastroparesis, indigestion, joint and muscle injury, arthritis, osteoarthritis, rheumatism, sprains, muscular aches, pains, cramps, hypertension, dementia, fever, infectious diseases, colic and helminthiasis.

Ginger main active compounds are non-volatile pungent principles, such as gingerols, shogaols, paradols, and zingerone. a number of preclinical investigations with a wide variety of assay systems and carcinogens have shown that ginger and its compounds possess chemopreventive and antineoplastic effects.

Mechanism of action (MOA): The cancer preventive activities of ginger are supposed to be mainly due to free radical scavenging, antioxidant pathways, alteration of gene expressions and induction of apoptosis. All of which contribute towards decrease in tumor initiation, promotion and progression.
Ginger powder side effects: Gas, bloating, heartburn and nausea.

References:
Crit Rev Food Sci Nutr. 2011 Jul;51(6):499-523
J BUON. 2011 Jul-Sep;16(3):414-24


Dr. Jeff Zhao (赵吉福), a natural product scientist, has been studying active ingredients, new drugs, cosmetics and  nutritional supplements for over 35 years.

Warning: The information in this web site is for your information only. You should not use our information to diagnose or treat any health problems or illnesses without consulting your medical doctors.​​​​

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