Cherry and papaya reduce gout attack by lowering plasma and urine urate

Health Science and Practical Remedies

Dr. Jacob RA at University of California at Davis and several other research institutes have found that cherry could be the strongest one for lowering and preventing the risk of recurrent gout attack comparing to kiwi, grapes and strawberry.

It have been found that cherry consumption may lower the risk of cancer, heart disease and other chronic diseases through their effects and abilities of antioxidant, anti-inflammatory, inhibiting human LDL oxidation and cyclooxygenase (COX),  scavenging the reactive nitric oxide (NO) radical, activating macrophages, also modulating tumor necrosis factor (TNF)-α secretion.

One study included 633 individuals with gout. Cherry intake over a 2-day period was associated with a 35% lower risk of gout attacks compared with no intake. The effect of cherry intake persisted across subgroups stratified by sex, obesity status, purine intake, alcohol use, diuretic use, and use of anti-gout medications. When cherry intake was combined with allopurinol use, the risk of gout attacks was 75% lower than during periods without either exposure. These findings suggest that cherry intake is associated with a lower risk of gout attacks.

Click here and find what are the pharmacological effects of papaya

Biological Effects of Cherry:
  • Promotes health, Activated macrophages
  • Alleviates arthritic pain and attacks of gouty arthritis, Anti-inflammatory
  • Increases the rate of renal glomerular urate filtration
  • Reduces tubular urate reabsorption
  • Inhibits NO production, Alters TNF-α production, Inhibits proinflammatory enzyme COX-2
  • Decreases plasma CRP (C-reactive protein)
  • Strong antioxidant in both lipophilic and hydrophilic systems
  • Restores ascorbic acid (Vitamin C) function by reduction of oxidized vitamin C
  • Reduces plasma urate (milk proteins also lowers serum urate, whereas purine-rich foods such as beef liver, haddock and soybeans increases serum urate)
Active compounds of cherry:
Sweet cherry (Prunus avium) contains essential vitamins, minerals, dietary fiber and other phytochemicals such as anthocyanins, catechins, chlorogenic acid, flavonal glycosides, melatonin, cyanidin and hydroxycinnamates. 1-O-(3,4-Dihydroxy-E-cinnamoyl)- 2,3-Cyclopentanetriol in the fruit of Prunus cerasus (cherry) is a strong antioxidant.
Public Health Nutr. 2009 Sep;12(9A):1656-62
Pharm Biol. 2012 Nov;50(11):1423-7
Arthritis Rheum. 2013 Apr;65(4):1135-6
Arthritis Rheum. 2012 Dec;64(12):4004-11
Arthritis Rheum. 2012 Dec;64(12):3827-30
Tex Rep Biol Med. 1950;8(3):309-11

Dr. Jeff Zhao (赵吉福), a natural product scientist, has been studying active ingredients, new drugs, cosmetics and  nutritional supplements for over 35 years.

Warning: The information in this web site is for your information only. You should not use our information to diagnose or treat any health problems or illnesses without consulting your medical doctors.​​​​


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